Adrenocortical Carcinoman abnormal tumor that develops in the adrenocortical duct of a man can include vaginal bleeding, an irregular menstrual cycle, and deepening of the voice. In men, the tumor may be located in the adrenal gland. Generally, there are no signs of the condition; however, symptoms may develop in women. Typically, patients with this cancer will experience vaginal bleeding, irregular menstrual periods, or deepening of the voice.
The disease is not inherited, and some patients have a hereditary tendency. About 10 percent of patients have signs of Cushing syndrome, including round face, double chin, generalized obesity, growth failure, and hypertension. Despite the fact that the exact cause of this condition is unknown, it is most often a result of a combination of environmental and genetic factors. Likewise, some types of adrenocortical tumor are caused by inherited conditions, such as neurofibromatosis, tuberous sclerosis, Sturge-Weber syndrome, and ataxia-telangiectasia. The prevalence of Li-Fraumeni syndrome is high among ACC patients, with about 50 to 80 percent of these patients having Li-Fraumeni syndrome.
The majority of adrenocortical carcinoma patients have no known cause. The majority of cases are sporadic, but may arise from a combination of environmental and genetic factors. Some tumors are inherited, such as neurofibromatosis and tuberous sclerosis, but are rare. In addition, Li-Fraumeni syndrome is common in pediatric ACC and is also associated with MEN1.
Some patients are genetically predisposed to the disease, but the vast majority of cases are sporadic. Children and adults with ACC typically have the disease at an earlier age. It is a highly aggressive disease that typically begins in childhood and progresses to adulthood. The symptoms of Adrenocortical CarcinomA are often accompanied by other symptoms, such as abdominal pain.
Among the symptoms of Adrenocortical CarcinomA are symptoms of the cancer in the adrenal gland. Some patients may have hereditary predisposition to the disease. In both men and women, ACC can occur at any age, but it is most common in adolescents. People with a family history of this disease should seek treatment to address any underlying symptoms.
The symptoms of Adrenocortical CarcinomA are usually unspecific. A few patients will experience only one or two symptoms in their lifetime. Approximately 10 percent of adrenocortical Carcinoma patients have Cushing Syndrome, which is characterized by a double chin, round face, and generalized obesity. Occasionally, tumors are a sign of an underlying disease. A doctor may order imaging studies to confirm a diagnosis.
Symptoms of Adrenocortical CarcinomA are unique to each patient. In some cases, the cancer does not produce hormones, so there are no symptoms. The other symptoms of Adrenocortical CancerA are a feeling of thirst and a decreased appetite. There may be an associated hormone or disorder, such as Cushing syndrome. If you do, however, have the tumor, seek treatment as soon as possible.
In most cases, Adrenocortical CarcinomA is nonfunctional. The tumor grows in the outer layer of the adrenal gland. It is found near the kidney and controls blood pressure and responses to stress. A tumor in the adrenal duct may cause sexual development. Some cancers may spread to the bones, lungs, or brain. Some patients may exhibit masculine characteristics and develop a syndrome called Li-Fraumeni.
