Parkinson’s disease affects nerves in the body, and these nerves produce the chemical norepinephrine. This chemical controls many bodily functions. This may explain the symptoms that are non-movement-related, such as irregular heartbeat, fatigue, and changes in blood pressure. People with Parkinson’s disease may also experience decreased movement of food through the digestive tract.
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Parkinson’s disease is hard to diagnose at early stages, so the doctor will likely perform a neurological exam and physical examination. The doctor will also be watching for changes in reflexes, muscle strength, and coordination. Depending on the symptoms, additional testing may be required, including brain imaging or blood tests.
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Another common symptom of Parkinson’s disease is tremor, which is a rhythmic shaking of the body. Other symptoms may include a slow, shortened stride when walking. The person may also have trouble identifying different smells. Patients with Parkinson’s disease may also experience fatigue and pain throughout their body.
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Early symptoms of Parkinson’s disease can be subtle and occur over a period of years. The signs may be difficult to notice, so it is important to consult a movement disorder specialist to rule out the disease. The most common early symptoms are tremors, slowness of movement, and muscle stiffness. Other symptoms may occur at any time.
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The involuntary rhythmic tremor that can occur in the hands, arms, and head is known as essential tremor. Essential tremor is often inherited. It affects the globus pallidus interna, which regulates muscle tone and is linked to the basal ganglia. The GPi controls glutamate levels and controls neuron-to-neuron communication. It can also affect micrographia, the ability to write small letters or numbers.
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Parkinson’s disease is caused by low or declining levels of dopamine, a natural neurotransmitter that is necessary for controlling movement. As the levels of dopamine decline, the disease symptoms get worse. As dopamine levels fall, nerve endings in the brain that produce norepinephrine may also be affected.
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The cause of Parkinson’s disease is still largely unknown, but genetics and environmental factors are suspected. Exposure to pesticides, herbicides, and other chemicals can all contribute to this condition. Although there is no cure for PD, medications can help patients with PD live a relatively normal life. It is important to see a physician if your symptoms persist or worsen. In addition to a physical examination, your doctor will probably perform a CT scan or an MRI to determine the extent of damage.
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As the disease progresses, medications become less effective and may even cause side effects. However, if the disease has progressed to the point that other treatments no longer help, surgery may be the only option. The main therapy for Parkinson’s disease is levodopa, which causes nerve cells to make more dopamine. Dopamine is essential for the brain to function, and levodopa restores this dwindling supply. Patients usually receive levodopa along with carbidopa, which reduces the risk of side effects such as nausea and lightheadedness.
