There are many reasons why you might have Parkinson’s disease, including age and genetics. It is also hereditary, but it does not always run in families. Parkinson’s disease is associated with low levels of dopamine, a neurotransmitter that sends messages to the part of the brain that coordinates bodily functions. As a result, patients with this condition have low levels of dopamine and norepinephrine, two hormones that control automatic body functions. Ultimately, the nerve endings in the brain become damaged, leading to symptoms like fatigue, constipation, and low blood pressure.
Scientists have linked faulty genes to PD in about 2% of cases. These genes are inherited from one or both parents. Some researchers believe that this gene is the cause of early onset of Parkinson’s disease in people with certain genetic conditions, including certain autoimmune diseases. While there is no conclusive evidence, researchers are working on identifying other genes that may play a role in Parkinson’s. This condition can also be caused by certain environmental factors, including smoking or cigarette smoke.
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Alzheimer’s disease is another common cause of Parkinson’s disease, and it is primarily caused by an imbalance in dopamine. This chemical is crucial in regulating the transmission of nerve impulses. As a result, the disease is often accompanied by cognitive impairment. The symptoms of Parkinson’s disease start decades before a person develops the motor impairments of the disease. In most cases, there is no cure for Parkinson’s disease, and therapies are not able to slow the progression of the disease.
Because the disease has no cure, most people with Parkinson’s disease eventually need to take medication called levodopa. Levodopa is absorbed by the nerve cells of the brain and converts into the chemical dopamine, which controls movement. As a result, raising dopamine levels can improve symptoms. Most people take levodopa together with other medications, which help treat the underlying cause of the disease.
Although aging is a major risk factor for developing Parkinson’s disease, some people get it earlier. Most people with PD develop the disease after the age of fifty. The disease often starts during middle or late life, with early onset occurring in younger people. The age of diagnosis for early onset PD is relatively low, with only four percent of cases occurring in people under the age of 50. This disease is not genetic, but can be acquired from exposure to certain chemicals.
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Researchers don’t know exactly why someone gets Parkinson’s disease, but they have determined that the disease is caused by damage to nerve cells in the substantia nigra area of the brain. Dopamine is a neurotransmitter that controls movement and is produced by the substantia nigra. Once these cells die, dopamine levels in the brain are lowered. When levels fall below this level, the brain begins to lose motor coordination.
In addition to levodopa, many people suffering from the disease may benefit from medications that slow down the breakdown of the neurotransmitter MAO-B. Levodopa may also help control jerky movements associated with Parkinson’s. However, amantadine is not for everyone, and may have side effects, such as leg swelling. If you are experiencing Parkinson’s disease, a combination of levodopa and amantadine may be the best choice for you.
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